Table 2. Proportion of Subjects with Good-Excellent Histological Improvement vs. Historical 5% Placebo rate–Day 84.
| Comparison to 5% Historical Placebo Response | n | Good or Excellent Improvement, n (%) | 90% CI | p-value |
|---|---|---|---|---|
| Placebo (N = 7) | 7 | 1 (14.3) | (0.73, 55.4) | — |
| SRT2104 250 mg (N = 9) | 6 | 3 (50) | (15.3, 84.7) | 0.0022 |
| SRT2104 500 mg (N = 12) | 9 | 4 (44.4) | (16.9, 74.9) | 0.0006 |
| SRT2104 1000 mg (N = 11) | 11 | 2 (18.2) | (3.33, 50.0) | 0.1019 |
| All Active (N = 32) | 26 | 9 (34.6) | (18.0, 54.2) | <0.0001 |
| Low Exposure (N = 15) | 12 | 5 (41.7) | (18.1, 70.6) | 0.0002 |
| High Exposure (N = 16) | 14 | 4 (28.6) | (10.4, 58.1) | 0.0042 |