Fig 2. Compound 2 treatment mediates recovery from L. major-induced disease progression in BALB/c mice.

Female BALB/c mice (total: n = 33) were infected with 5 × 10⁶ L. major promastigotes into the right hind footpad. On d 21 post infection BALB/c mice were either treated intraperitoneally with 50 mg/kg compound 2 (■) (n = 11), 50% DMSO/PBS (□) (n = 11) or left untreated (▲) (n = 11). Individual treatment was repeated on d 25 and d 28 post infection. A. Footpad swelling (difference between infected and non-infected footpad in mm) and B. body weight (g) was determined twice a week to monitor clinical manifestation of CL. n = number of animals.