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. 2015 Jun 12;1(5):e1500447. doi: 10.1126/sciadv.1500447

Fig. 2. BAF complexes change their subunit composition during development.

Fig. 2

Murine ES cells have a specific subunit composition (esBAF) that is apparently not found in other cell types to date. Overexpression of the esBAF subunits can facilitate induction of pluripotent cells from fibroblasts. In neural stem cells that line the developing neural tube, a second form of BAF complexes is found that again is distinguished, but not by subunits expressed only in neural progenitors, but rather an assembly that appears to be found only in neural progenitors. In postmitotic neurons, three subunits found only in neurons are present in complexes immediately after mitotic exit. These include BAF53b, BAF45b, and CREST. In cardiac progenitors, complexes are distinguished by the expression of BAF60c, whereas in hematopoietic stem cells, complexes contain Brm, but not Brg, and BAF60b and BAF60c, but not BAF60a, and Bcl7b and Bcl7c, but not Bcl7a.