Skip to main content
. 2015 Jun 12;1(5):e1500447. doi: 10.1126/sciadv.1500447

Fig. 6. Mechanism of synergy between BAF and TopoII and its loss in common cancers bearing BAF subunit mutations.

Fig. 6

On the left is the normal mechanism of TopoII function. On the right is the mechanism when an oncogenic BAF subunit is mutated. BAF is necessary for binding of TopoIIa to DNA at 11,000 of 16,000 sites over the genome. When TopoII fails, it leads to the inability to resolve tangled DNA and the production of anaphase bridges, as shown in the inset. The mechanism by which DNA is repaired after possibly being cleaved in the cytoplasm by cytoplasmic DNase is unclear, but might be error-prone and lead to an accumulation of mutations.