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. 2015 Nov 10;10(11):e0142406. doi: 10.1371/journal.pone.0142406

Fig 6. Changes in Pak1 expression occur in multiple solid tumors.

Fig 6

(A–J) GSE19188 data sets for E2F1 (A) and Pak1 (B) expression in NSCLC tumor and adjacent normal samples were ranked from most normal to most tumor-like. Samples 1–58 are the adjacent normal tissues (black diamonds), whereas samples 59–145 represent tumor samples (light gray diamonds). Gene expression was determined via microarray for E2F1 (C, G, E, I) and Pak1 (D, F, H, J). Oncomine (http://www.oncomine.org, Compendia Bioscience, Ann Arbor, MI, USA) was used for analysis and visualization of E2F1 and Pak1 expression in 4 common solid tumor types. (C, D) Analysis of E2F1 (C) and Pak1 (D) expression in normal lung versus squamous cell lung carcinoma from the Bhattacharjee lung database. (E, F) Analysis of E2F1 (E) and Pak1 (F) expression in normal lung versus squamous cell lung carcinoma from the Hou lung database. (G, H) Analysis of E2F1 (G) and Pak1 (H) expression in normal lung versus lung adenocarcinoma from the Stearman lung database. (I, J) Analysis of E2F1 (I) and Pak1 (J) expression in normal breast versus invasive breast carcinoma from the TCGA breast database.