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In vivo tumor growth inhibition in two subcutaneous xenograft tumor models. Nonradioactive 175Lu was loaded into LCP NPs to act as a vehicle control. One dose per mouse was delivered intravenously on Day 0 (arrows). A) Human UMUC3 bladder cancer supplemented with murine 3T3 fibroblasts. B) Human H460 non-small cell lung cancer. Initial tumor sizes ~100–150 mm3; n = 5–8; †p<0.03, ‡p<5e-5, *p<0.015.
