Fig. 4.
Effect of GHRH agonist MR-409 in the transplanted NOD/SCID mice. (A) Blood glucose follow-up (average ± SEM) in the diabetic mice after transplantation. Control (C, ●); M (○); and M + T (▼). Transplantation was conducted at day 0, animals in the group M + T were injected s.c. with 10 μg/day of MR-409 from day 2 to day 24. The horizontal line represents the average blood glucose level in nondiabetic mice (147.3 ± 7.6 mg/dL, n = 25). (B) Average weekly blood glucose, the data represent the average glucose of three measurements per week (mean ± SEM). Open box, control; light gray box, group M, and gray box, group M + T. −D1, 1 d before transplantation. (C) The IPGTT performed at 2 wk after transplantation.