Fig. S1.

Effect of GHRH agonists on INS-1 cell viability and proliferation. (A) INS-1 cells were treated by MR agonists and JI-36 at concentrations indicated for 24 h. Total numbers of proliferating cells were measured using the BrdU incorporation assay. Values are shown as percentages of control. (B) INS-1 cells were treated with MR-356 at indicated concentrations in the presence or absence of 2 μM GHRH antagonist, MIA-602. Relative percentages were calculated by comparing the number of viable cells in the treatment to that in the control. Data were averaged from at least three individual tests done in quadruplicate for each test.