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. 2015 Oct 19;112(44):E6010–E6019. doi: 10.1073/pnas.1519159112

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Fig. 5. — veQTLs are involved in epistatic interactions with cis variants. (A–D) Scatter plots of Ser12 (2L:2250431.0.2251275) expression in females versus eQTL or veQTL genotypes. (A) The effect of a cis-eQTL (2L_2251218_SNP) on the mean but not on the variance of expression in individuals carrying the same genotypes. (B) The effect of a trans-veQTL (2L_11857529_SNP) on the variance but on not the mean of expression in individuals carrying the same genotypes. (C) The effect of the trans-veQTL on the mean expression is dependent on the cis-eQTL genotype. (D) The effect of the cis-eQTL on the mean expression is dependent on the trans-veQTL genotype. (E and F) Scatter plots of Fatp (2L:10510672.0.10517218) expression in males versus eQTL or veQTL genotypes. (E) A cis variant (2L_10510716_SNP) has no effect on the mean or variance of expression. (F) The effect of a trans-veQTL (3L_17881605_SNP) on the variance but not on the mean of expression. (G) The effect of the trans-veQTL on the mean expression is dependent on the cis variant genotype. (H) The effect of the cis variant on the mean expression is dependent on the trans-veQTL genotype.