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. 2015 Nov 10;10(11):e0142252. doi: 10.1371/journal.pone.0142252

Table 1. Correlation between NUSAP1 expression and parameters in OSCCs.

Results of immunostaining
No. patients
Clinical classification Total NUSAP1(-) NUSAP1(+) p value
Age at surgery (years)
<60 19 7 (35%) 12 (65%) 0.214
60–70 27 5 (17%) 22 (83%)
70> 24 4 (20%) 20 (80%)
Gender
Male 40 9 (25%) 31 (75%) 0.512
Female 30 7 (20%) 23 (80%)
T-primary tumor size
T1 5 1 (20%) 4 (80%) 0.204
T2 37 12 (32%) 25 (68%)
T3 13 2 (10%) 11 (90%)
T4 15 1 (6%) 14 (94%)
T1+T2 42 13 (33%) 29 (67%) 0.048*
T3+T4 28 3 (8%) 25 (92%)
N-regional lymph node
Negative 39 11 (25%) 28 (75%) 0.533
Positive 31 5 (21%) 26 (79%)
TNM stage
I 5 1 (20%) 4 (80%) 0.691
II 25 6 (24%) 19 (76%)
III 21 4 (25%) 17 (75%)
IV 19 5 (21%) 14 (79%)
Histopathological type
Well-differentiated 43 9 (21%) 34 (79%) 0.456
Moderately differentiated 16 5 (36%) 11 (64%)
Poorly differentiated 11 2 (22%) 9 (78%)
Tumoral site
Gingiva 15 3 (20%) 12 (80%) 0.552
Tongue 40 10 (25%) 30 (75%)
Buccal mucosa 6 1 (17%) 5 (83%)
Oral floor 9 2 (22%) 7 (78%)
Total 70 16 54

NUSAP1(-), down-regulated NUSAP1; NUSAP1(+), up-regulated NUSAP1.

*p < 0.05. (χ2 test).