Skip to main content
. 2015 Nov 10;10(11):e0142118. doi: 10.1371/journal.pone.0142118

Fig 1. Varying genomic organization of HIV-1 in the intergenic region between rev1 and vpu.

Fig 1

(A) The relative position of genes within HIV-1 subtype C clones ZM246F-10 (upper panel) and ZM247Fv-1 (lower panel) is shown. Whereas ZM246 rev1 (green) and vpu (blue) lie within different reading frames and are separated by an intervening stop codon (*), ZM247 encodes a rev1-vpu fusion gene. Frameshift mutations that were introduced to generate or disrupt rev1-vpu in ZM246 and ZM247, respectively, are highlighted in yellow. (B) Putative topology of the Rev1-Vpu fusion protein and its parental proteins Rev (green) and Vpu (blue).