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. Author manuscript; available in PMC: 2015 Nov 10.
Published in final edited form as: Int J Cancer. 2015 May 6;137(7):1587–1597. doi: 10.1002/ijc.29535

Figure 3.

Figure 3

SLC1A5 blockade induces apoptotic cell death. (a) Cell cycle analysis of four cell lines before and after treatment with 500 μM GPNA. GPNA induces cell death in A549 cells and HCC15 (subG1) while has no significant effect on bronchial airway epithelial cell lines. (b) Induction of nuclear condensation and fragmentation by 500 μM GPNA over 4 days shown in A549 but not in 16HBEs. (c) Dose-dependent increase of Caspase 9 cleavage following exposure to GPNA at indicated concentration (arrows point to cleaved forms, 37 and 35 kDa).