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. 2015 Sep 16;35(37):12779–12791. doi: 10.1523/JNEUROSCI.4501-14.2015

Figure 8.

Figure 8.

Inhibition of SK improves cholinergic excitability in TgCRND8 mice. A, Representative example of cell firing elicited by bath application of 1 mm ACh (15 s) in WT (top, blue trace), TgCRND8 (middle, red trace), and a TgCRND8 cell in the presence apamin (bottom, black trace). Traces represent the first 15 s of ACh-elicited firing. B, Apamin induces a rightward shift of the cumulative probability distribution of ACh-elicited firing frequency in TgCRND8 (K–S test, p < 0.00001; TgCRND8 control, n = 15 cells, TgCRND8 + Apamin, n = 8 cells).