Neutrophils lacking DOCK2 and DOCK5 are capable of normal adhesion. BM neutrophils from WT, DOCK2−/−, DOCK5−/−, and DKO mice were incubated on the ICAM-1 or C3bi-coated plates for 30 min at 37°C in the presence or absence of fMLF (10 μM) or PMA (162.12 nM). After being washed twice with HBSS containing 20 mM HEPES (pH 7.4) and 0.1% BSA, the percentage of adherent cells was compared among WT, DOCK2−/−, DOCK5−/−, and DKO neutrophils. Data are indicated as means ± SEM of three independent experiments.