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. Author manuscript; available in PMC: 2015 Nov 10.
Published in final edited form as: Neurobiol Dis. 2015 Jul 15;82:332–341. doi: 10.1016/j.nbd.2015.07.002

Figure 1. Behavioural phenotype of the BALB/c mice following UCMS and imipramine treatment.

Figure 1

Self-oriented behaviours, locomotor activity and weight of BALB/c mice of control mice (n=14–15) and stressed mice (n=11–15) treated with saline or imipramine (20mg/kg/day) at the end of the 9 week of the UCMS procedure. (A) The nest building ability (self-oriented behaviour) of control and stressed mice was scored after 24h using the Deacon scale. A score of 0 represents a complete lack of nest building while a score of 5 was given for a perfect nest. Data represents mean ±SEM. *p<0.05 Kruskal-Wallis H test. (B) Home cage locomotor activity of the animals was measured using an actograph for a 2 hour period. Data presented as mean ±SEM. No significant changes were observed. (C) The overall coat state of the animals was measured before initiating the imipramine treatment (after 2 weeks of UCMS) and at the end of the UCMS procedure for vehicle and imipramine treated mice (after the 9 week paradigm). A score of 0 was given to region where the coat was in a good state while a score of 1 was given for each region with poor condition. A total of 7 areas were scored for each animal. Data represents mean ±SEM. *p<0.05, ***p<0.01, Kruskal-Wallis H test. (D) Body weight of control and stressed mice treated with vehicle or imipramine at the end of the 9 week paradigm. Data represents mean ±SEM.