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. Author manuscript; available in PMC: 2016 Nov 14.
Published in final edited form as: FEBS Lett. 2015 Aug 20;589(22):3419–3432. doi: 10.1016/j.febslet.2015.08.015

Figure 3. Minimum reaction mechanism for carbapenem hydrolysis by mono-Zn(II)-B2 enzymes.

Figure 3

The arrangement of water molecules is based on the crystallographic structures of CphA, free and in complex with hydrolyzed biapenem [47,61], and of the free form of Sfh-I [62]. W1 stands for Wat1 and W2 stands for Wat2.