Figure 3. Infusion of muscimol into mPFC blocks the antidepressant actions of systemic scopolamine.
The influence of the neuronal silencing agent, muscimol, infused into mPFC subregions of rat on the antidepressant response to systemic scopolamine (i.p.) was determined. The experimental design is shown at the top. Muscimol was infused 1 hr prior to scopolamine administration and immobility in the FST was determined 24 hr later. (A) Infusion of muscimol into the IL (A) or PrL (B) significantly blocked the decrease in immobility resulting from scopolamine administration. Results are the mean ± S.E.M., n = 10 per group. * p < 0.05 compared to controls (ANOVA and Newman-Keuls post hoc test).