Table 7.
Summary of the osteogenic response to Bmp2 conditional knockout
Bmp2 conditional knockout | |||
---|---|---|---|
Osteogenic Condition | All cells, inducible; UBC-Cre-ERT | Osteoblasts/Osteocytes after P21; Osx-Cre-TetO | Vascular endothelial cells; VEC-Cre |
Fracture healing (endochondral) | Strongly Affected no callus |
Normal | Normal |
Stress fracture healing (intramembranous woven bone) | Normal | Mildly Affected slightly reduced expression of Bsp, woven bone BMD |
Normal |
Non-damaging mechanical loading (lamellar bone) | Normal | Normal | (not tested) |