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. Author manuscript; available in PMC: 2016 Dec 1.
Published in final edited form as: Bone. 2015 Sep 5;81:533–543. doi: 10.1016/j.bone.2015.09.003

Table 7.

Summary of the osteogenic response to Bmp2 conditional knockout

Bmp2 conditional knockout
Osteogenic Condition All cells, inducible; UBC-Cre-ERT Osteoblasts/Osteocytes after P21; Osx-Cre-TetO Vascular endothelial cells; VEC-Cre
Fracture healing (endochondral) Strongly Affected
no callus
Normal Normal
Stress fracture healing (intramembranous woven bone) Normal Mildly Affected
slightly reduced expression of Bsp, woven bone BMD
Normal
Non-damaging mechanical loading (lamellar bone) Normal Normal (not tested)