Table 1.
Bilateral nigrostriatal pathology observed after unilateral intrastriatal PFF injection.
| Regional Effect | Timepoint | Ipsilateral | Contralateral |
|---|---|---|---|
| Substantia Nigra | |||
| Hyper-phosphorylated α-syn accumulations | 1, 2 & 6 Months | Y | N |
| TH+ Neuron Loss | 6 Months | Y | Y |
| TH+ Dendrite Loss | 6 Months | Y | N |
| Striatum | |||
| TH+ Terminal Density Reduction | 6 Months | Y | Y |
| Diminished Dopamine Levels | 6 Months | Y | N |
| Dopamine Metabolite Deficits | 6 Months | Y (HVA) Y (DOPAC) |
Y (HVA) N (DOPAC) |
| Dopamine Turnover Deficits | 6 Months | N | Y |
Abbreviations: Y=yes/present; N=no/not present; HVA=homovanillic acid; DOPAC= 3,4-Dihydroxyphenylacetic acid; d=days; α-syn=alpha-synuclein