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. Author manuscript; available in PMC: 2015 Dec 1.
Published in final edited form as: Oral Surg Oral Med Oral Pathol Oral Radiol. 2015 May 28;120(6):e235–e239. doi: 10.1016/j.oooo.2015.05.006

Fig. 4.

Fig. 4

Mechanism for GALNT3 mutations causing hyperphosphatemic familial tumoral calcinosis (HFTC). HFTC can be caused by mutations in GALNT3, FGF23, or KL (FGF23 receptor klotho). GALNT3 is a Golgi enzyme that is required for the O-glycosylation of FGF23. Glycosylation of FGF23 protects it from proteolytic inactivation that results in elevated serum phosphate (causing HFTC).