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. Author manuscript; available in PMC: 2016 Oct 1.
Published in final edited form as: Neurobiol Dis. 2015 Jun 6;82:152–163. doi: 10.1016/j.nbd.2015.05.020

Figure 4. Scyllo-inositol inhibits soluble.

Figure 4

A β oligomer-induced glutamate receptor internalization in hippocampal neurons. (A) Confocal images of surface-labeled Aβ (detected by 3D6, red), surface-labeled GluA1 (green) and total VGLUT2 (blue) in hippocampal neurons (DIV18) after 12 hr treatment with synthetic wt Aβ40 or (Aβ40 S26C)2 dimer with or without co-administration of chiro- or scyllo-inositol (20 μM). Scale bar, 10 μm. (B) and (C) Bars: mean intensity of surface GluA1, total VGLUT2 (B) and surface-labeled Aβ (C) under indicated conditions of treatment. * significantly different from neurons without treatment (p < 0.05 by one-way ANOVA test). Fifteen cells per condition were analyzed. Error bars, s.e.m.