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. Author manuscript; available in PMC: 2016 Oct 1.
Published in final edited form as: Neurobiol Dis. 2015 Jun 6;82:152–163. doi: 10.1016/j.nbd.2015.05.020

Figure 7. Scyllo-inositol inhibits Aβ oligomer-induced synaptic loss in vivo.

Figure 7

(A) and (B) Confocal micrographs showing the pattern of pre-synaptic puncta labeled by VGLUT2 (green), post-synaptic puncta labeled by GluA1 (red), and DAPI (blue) in the molecular layer of CA3 (A) or DG (B) of hippocampus 4 day after ICV injection with synthetic WT Aβ40 or (Aβ40 S26C)2 dimer in the presence or absence of chiro- or scyllo-inositol (20 μM). Scale bar, 20 μm. Bars: mean density of VGLUT2, GluA1 and co-localized synaptic puncta under different conditions. * significantly different from those of mice injected with aCSF (p < 0.05 by one-way ANOVA test). Fifteen slices per condition were analyzed. Error bars, s.e.m.