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. Author manuscript; available in PMC: 2016 May 1.
Published in final edited form as: J Invest Dermatol. 2015 Jun 8;135(11):2824–2833. doi: 10.1038/jid.2015.207

Figure 4. LC facilitation of p53 island growth is T cell independent.

Figure 4

Mutant KC p53 island density (a) and area (b) were quantified in epidermal sheets prepared from TCRβ−/−δ−/−.NLC and TCRβ−/−δ−/−.DTA mice following 5 or 9 wks UVB exposure (400 J/m2, 3x/wk). Inset graphs show distribution at 9 wks; each symbol represents one mouse. LC-intact TCRβ−/−δ−/−.NLC mice have increased p53 island density and area compared to LC-deficient TCRβ−/−δ−/−.DTA mice following 9wks UVB; ***P<0.001. (c) CD207+ LC density is increased in association with p53 islands. (d, e) Epidermal cells prepared from untreated vs 5 wk chronic UVB treated TCRβ−/−δ−/−.NLC and TCRβ−/−δ−/−.DTA mice were examined for changes in gene expression (relative to untreated TCRβ−/−δ−/−.DTA) by qRT-PCR; each symbol represents one mouse,**P<0.01, ***P<0.001, Holm-Sidak correction for multiple comparisons.