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. Author manuscript; available in PMC: 2016 Dec 1.
Published in final edited form as: Bone. 2015 Jul 13;81:152–160. doi: 10.1016/j.bone.2015.07.012

Table 2.

Static and Dynamic Histomorphometric Results of Ulnar Loading on Non-Diabetic Akita Male and Female Mice

Female Data WT Females (n=5) Akita Females (n=7) p Values or Pairwise Comparisons
nonloaded loaded Δ (loaded-nonloaded) nonloaded loaded Δ (loaded-nonloaded) WT Females (loaded vs. nonloaded) Akita Females (loaded vs. nonloaded) nonloaded ulnae (Akita vs. WT) Δ (loaded-nonloaded) (Akita vs. WT)
Ct.T.Ar (mm2)
0.255 (0.010) 0.289 (0.019) 0.034 (0.028) 0.257 (0.023) 0.266 (0.021) 0.008 (0.015) 0.05 0.2 0.9 0.6
Ct.B.Ar (mm2)
0.218 (0.007) 0.252 (0.016) 0.033 (0.022) 0.215 (0.014) 0.229 (0.010) 0.013 (0.012) 0.03 0.02 0.7 0.1
Ct.Ma.Ar (mm2)
0.369 (0.004) 0.037 (0.004) 0.0006 (0.007) 0.042 (0.011) 0.037 (0.013) −0.005 (0.005) 0.9 0.03 0.4 0.4
Ct.Th (μm)
160.17 (4.10) 176.04 (4.80) 15.87 (6.19) 156.34 (5.25) 166.57 (8.51) 10.23 (6.31) 0.005 0.005 0.2 0.1
Ps.MS/BS (%)
12.55 (5.30) 36.60 (5.43) 24.05 (8.83) 20.02 (3.03) 49.83 (8.86) 29.81 (7.14) 0.01 0.0006 0.02 0.3
Ps.MAR (μm/day)
0 (0) 0.942 (0.506) 0.942 (0.506) 0.050 (0.133) 0.668 (0.396) 0.617 (0.396) 0.01 0.009 1 0.3
Ps.BFR/BS (μm3/μm2/day)
0 (0) 0.364 (0.221) 0.364 (0.221) 0.013 (0.036) 0.362 (0.226) 0.348 (0.222) 0.01 0.005 1 0.8
Ec.MS/BS (%)
9.51 (3.77) 16.91 (5.90) 7.40 (5.00) 17.06 (7.88) 43.96 (10.93) 26.90 (17.33) 0.06 0.001 0.05 0.1
Ec.MAR (μm/day)
0.155 (0.215) 0.0670 (1.011) 0.540 (0.909) 0.428 (0.380) 0.789 (0.324) 0.361 (0.426) 0.5 0.2 0.2 0.8
Ec.BFR/BS (μm3/μm2/day)
0.024 (0.037) 0.129 (0.186) 0.104 (0.160) 0.090 (0.083) 0.393 (0.200) 0.303 (0.230) 0.5 0.0006 0.1 0.1
Male Data WT Males (n=7) Akita Males (n=5) p Values of Pairwise Comparisons
nonloaded loaded Δ (loaded-nonloaded) nonloaded loaded Δ (loaded-nonloaded) WT Males (loaded vs. nonloaded) Akita Males (loaded vs. nonloaded) nonloaded ulnae (Akita vs. WT) Δ (loaded-nonloaded) (Akita vs. WT)
Ct.T.Ar (mm2)
0.258 (0.012) 0.285 (0.009) 0.027 (0.017) 0.245 (0.013) 0.242 (0.013) −0.002 (0.015) 0.01 0.7 0.1 1
Ct.B.Ar (mm2)
0.220 (0.008) 0.250 (0.008) 0.030 (0.011) 0.203 (0.008) 0.205 (0.004) 0.003 (0.010) 0.0004 0.6 0.005 0.005
Ct.Ma.Ar (mm2)
0.038 (0.007) 0.035 (0.008) −0.003 (0.008) 0.042 (0.012) 0.037 (0.011) −0.005 (0.006) 0.3 0.2 0.5 0.3
Ct.Th (μm)
158.16 (5.80) 176.49 (10.15) 18.34 (6.66) 147.49 (8.83) 152.79 (11.37) 5.30 (6.68) 0.0003 0.2 0.2 0.01
Ps.MS/BS (%)
22.02 (9.28) 52.77 (18.82) 30.75 (23.01) 14.45 (1.67) 31.69 (6.86) 17.24 (7.55) 0.001 0.008 0.1 0.4
Ps.MAR (μm/day)
0.290 (0.502) 1.001 (0.616) 0.711 (0.740) 0.135 (0.303) 0.064 (0.144) −0.071 (0.366) 0.04 1 0.6 0.07
Ps.BFR/BS (μm3/μm2/day)
0.098 (0.151) 0.642 (0.571) 0.544 (0.608) 0.025 (0.055) 0.028 (0.064) 0.004 (0.094) 0.02 1 0.6 0.02
Ec.MS/BS (%)
7.65 (4.61) 17.03 (9.20) 9.38 (9.09) 2.23 (1.13) 22.27 (16.38) 20.04 (17.43) 0.1 0.008 0.03 0.3
Ec.MAR (μm/day)
0.094 (0.163) 0.399 (0.338) 0.305 (0.442) 0 (0) 0.446 (0.327) 0.446 (0.327) 0.1 0.05 0.6 0.7
Ec.BFR/BS (μm3/μm2/day)
0.010 (0.018) 0.110 (0.114) 0.100 (0.125) 0 (0) 0.155 (0.160) 0.155 (0.160) 0.05 0.05 0.6 0.7

Note: Data are presented as mean (standard deviation). Pairwise comparisons were performed using either Student's t tests (shaded with light blue) or Mann-Whitney U tests for normally or non-normally distributed data, respectively.