Table 1.
Characteristics of patients with and without eosinophilia while undergoing outpatient parenteral antimicrobial therapy (OPAT).
| All (N=824) | Eosinophilia (N=210) |
No Eosinophilia (N=614) |
P-value† | |
|---|---|---|---|---|
| Age, med [IQR] | 60 [48–71] | 64 [53–74] | 59 [46–70] | 0.0002 |
| Male gender, N (%) | 494 (60) | 121 (58) | 373 (61) | 0.46 |
| Days of therapy, med [IQR] | 41 [31–45] | 42 [37–47] | 41 [29–44] | <0.0001 |
| Number of initial antimicrobials, med [IQR] ‡ | 1 [1–2] | 1 [1–2] | 1 [1–2] | 0.38 |
| Discharged to, N (%) | 0.003 | |||
| Home | 470 (58) | 102 (49) | 368 (61) | |
| Skilled nursing facility | 339 (42) | 105 (51) | 234 (39) | |
| Infectious Diagnosis, N (%) | ||||
| Orthopedic infections§ | 464 (56) | 129 (61) | 335 (55) | 0.09 |
| Bacteremia | 161 (20) | 36 (17) | 125 (20) | 0.36 |
| Skin/soft tissue infections | 122 (15) | 23(11) | 99(16) | 0.07 |
| Endocarditis | 82 (10) | 23 (11) | 59 (10) | >0.50 |
| Meningitis or encephalitis | 36 (4) | 11 (5) | 25 (4) | 0.44 |
| Pneumonia/empyema | 36 (4) | 9(4) | 27(4) | >0.50 |
| Intraabdominal infections | 34 (4) | 5 (2) | 29 (5) | 0.16 |
| Lyme disease | 28 (3) | 2 (1) | 26 (4) | 0.03 |
| Epidural abscess | 24 (3) | 9 (4) | 15 (2) | 0.23 |
| Urinary tract infections | 22 (3) | 3(1) | 19(3) | 0.32 |
| Otitis/sinusitis | 18 (2) | 4 (2) | 14 (2) | >0.50 |
| Vascular graft infection | 14 (2) | 6 (3) | 8 (1) | 0.21 |
| Mycobacterial lung infection | 8 (1) | 3 (1) | 5 (<1) | 0.43 |
| Organism, N (%) | ||||
| Gram positive | 641 (78) | 167 (80) | 474 (77) | >0.50 |
| Gram negative | 181 (22) | 42 (20) | 139 (23) | 0.44 |
| Anaerobe | 178 (22) | 43 (20) | 135 (22) | >0.50 |
| Fungal | 52 (6) | 14 (7) | 38 (6) | >0.50 |
| Mycobacterium | 9 (1) | 3 (1) | 6 (1) | >0.50 |
| Other‖ | 31 (4) | 2 (1) | 29 (5) | 0.01 |
| No organism or not collected | 63 (8) | 17 (8) | 46 (7) | >0.50 |
†
Wilcoxon-Rank Sum test or Fisher's Exact test, as appropriate.
‡
Number of antimicrobials begun during the initial four days of antimicrobial treatment
§
Orthopedic infections includes osteomyelitis, prosthetic joint infections, septic/arthritis, post-operative spine infections, and infections after fracture/fixation.
‖
Other includes Treponema pallidum, Borrelia burgdorferi, and viral organisms.