Table 2.
mRNAs expressed at higher levels in Gjb1−/Y//Gjc2−/− cerebella map to oligodendrocytes or oligodendrocytes precursor cells.
The table shows the genes in Gjb1−/Y//Gjc2−/− mice ranked by fold change (FC) in the levels of detected mRNA, and shows the false discovery rate (FDR), adjusted p value for each mRNA, and their expression, mostly based on the work of (Xu, et al. 2014) and (Zhang, et al. 2014). N/A indicates that mRNA was not mapped to cells by (Zhang, et al. 2014). OL: oligodendrocytes; AS: astrocytes; OPCs: oligodendrocytes precursor cells
| Name | FC | FDR | P | CSEA | expression(Zhang, et al. 2014); function |
|---|---|---|---|---|---|
| Bfsp2 | 3.1 | 0 | 0.06 | OL, OPCs | All CNS cells but more enriched in newly formed OL, myelinating OL and OPCs; cytoskeletal component |
| 2210011C24Rik | 2.7 | 0 | 0.003 | OL | N/A; unclassified gene |
| Fam46a | 2.3 | 0 | 0.002 | OL | CNS, but not restricted to one cell type; uncharacterized function |
| Ctsc | 2.2 | 0.2 | 0.04 | OL | All CNS cells but not enriched in newly formed OL or myelinating OL; dipeptidyl aminopeptidase |
| Tmem176a | 2.1 | 0 | 0.01 | OPCs | CNS, but not restricted to one cell type; dendritic cells/carcinoma antigen |
| Pbk | 1.9 | 0 | 0.02 | OPCs | All CNS cells but more enriched in OPCs; lymphokine- activated killer T cells originated PDZ-binding kinase |
| Pdlim2 | 1.9 | 1.2 | 0.1 | OL | All CNS cells but more enriched in myelinating OL and newly formed OL; STAT-interacting protein |
| Cdk1 | 1.9 | 0 | 0.006 | OPCs | All CNS cells but more enriched in endothelial cells; cyclin- dependent kinase |
| Npas1 | 1.9 | 0.3 | 0.03 | OPCs | All CNS cells but more enriched in Neurons, OPCs, and newly formed OL; transcription factor |
| Rab32 | 1.9 | 1 | 0.09 | OPCs | All CNS cells but more enriched in microglia; controls trafficking to lysosomes |
| AA986860 | 1.8 | 0.6 | 0.05 | OL | All CNS cells but more enriched in myelinating OL; uncharacterized function |
| Ada | 1.8 | 0 | 0.01 | OL | CNS, but not restricted to one cell type; adenosine deaminase, present in high levels in lymphocytes |
| Sh3gl3 | 1.8 | 0 | 0.002 | OL | All CNS cells but more enriched in myelinating OL and newly formed OL; implicated in endocytosis |
| 9630013A20Rik | 1.8 | 0 | 0.006 | OPCs | Myelinating OL, new formed OL and OPCs; unclassified gene |
| Fam111a | 1.8 | 0 | 0.01 | OPCs | All CNS cells but more enriched in endothelial cells; governs parathyroid hormone production & calcium homeostasis, |
| Prima1 | 1.7 | 1.2 | 0.1 | OL | All CNS cells but more enriched in myelinating OL and newly formed OL; membrane anchor of acetylcholinesterase in the brain |
| Dct | 1.7 | 0 | 0.006 | OPCs | Newly formed OL, myelinating OL and OPCs; tyrosine- related protein |
| Lcp1 | 1.7 | 0 | 0.003 | OL | All CNS cells but more enriched in microglia; actin-binding protein |
| Prickle1 | 1.6 | 0 | 0.009 | OL | All CNS cells but more enriched in newly formed OL and myelinating OL; nuclear receptor linked to myoclonic epilepsy |
| Cd9 | 1.6 | 0 | 0.004 | OL | All CNS cells but more enriched in newly formed OL; leukocyte surface glycoprotein |
| Top2A | 1.6 | 0.2 | 0.01 | OPCs | CNS, but not restricted to one cell type; DNA topoisomerase |
| Hebp1 | 1.6 | 6.6 | 0.4 | OL | All CNS cells but more enriched in microglia; promotes chemotaxis in monocytes and dendritic cells |
| Cdca5 | 1.6 | 1.8 | 0.05 | OPCs | CNS, but not restricted to one cell type ; cell cycle-associated protein |
| TnfAIP6 | 1.6 | 0.3 | 0.017 | OL | CNS, but not restricted to one cell type; hyaluronan-binding protein |
| Tgfbi | 1.6 | 0 | 0.006 | OL | All CNS cells but more enriched in microglia; inhibit cell adhesion |
| Gpr17 | 1.6 | 0 | 0.006 | OPCs | Myelinating OL, newly formed OL, and OPCs, also in neurons; leukotriene receptor |
| Gng8 | 1.6 | 1.8 | 0.07 | OL | All CNS cells but more enriched in myelinating OL and newly formed OL; G protein involved in transmembrane signaling |
| Cdca3 | 1.6 | 1.2 | 0.05 | OPCs | All CNS cells but more enriched in OPCs; cell cycle- associated protein |
| Opalin | 1.5 | 2.6 | 0.1 | OL, OPCs | Myelinating OL, newly formed OL; myelin paranodal protein |
| Serinc5 | 1.5 | 0.7 | 0.02 | OL, OPCs | All CNS cells but more enriched in newly formed OL, OPCs and myelinating OL; incorporation of serine into phosphatidylserine and sphingolipids |
| Ppp1r16b | 1.5 | 1.8 | 0.07 | OL | All CNS cells but more enriched in newly formed OL, myelinating OL and OPCs; protein phosphatase regulatory subunit |