Table 3.
mRNAs that were higher in Gjb1−/Y//Gjc2−/− cerebella that map to immune cells.
The table shows the genes in Gjb1−/Y//Gjc2−/− mice ranked by fold change (FC) in the levels of detected mRNA, and shows the false discovery rate (FDR), adjusted p value for each mRNA, and their expression, that map to layer 5a cortical neurons and/or immune cells by the CSEA tool, and is known to map to immune cells based on previous reports, mostly based on the work of (Beutner, et al. 2013) and (Hickman, et al. 2013), and maps to immune cells based on DAVID, and is also known to be involved in immune biological processes based on the Panther classification tool. N/A indicates that the mRNA was not reported to map to immune cells by DAVID or Panther.
| name | FC | FDR | p | DAVID (expression) |
enriched in immune cells/associated immune process |
|---|---|---|---|---|---|
| Tyrobp | 5.0 | 0 | 0.0002 | brain, mast cells | N/A |
| Ly86 | 4.2 | 00 | 0.0006 | B-cells | lymphocyte antigen 86 |
| Fcrls | 3.9 | 0 | 0.0006 | diencephalon | Fc receptor-like S, scavenger receptor; lymphocytes activation, B-cell meditated immunity |
| Slc11a1 | 3.7 | 0 | 0.0006 | pre B-cells | also known as natural resistance-associated macrophage protein 1. |
| Fcer1g | 3.6 | 0 | 0.002 | mast cells | Fc receptor, IgE, high affinity I, gamma polypeptide |
| Fcgr2b | 3.6 | 0 | 0.001 | macrophages, mast cells |
Fc receptor, IgG, low affinity IIb; lymphocyte activation, B-cell meditated immunity |
| Ctss | 3.6 | 0 | 0.001 | brain | cathepsin S; antigen processing and presentation via MHC class II proteolysis |
| Blnk | 3.4 | 0 | 0.001 | lymphoid | B-cell linker |
| Irf8 | 3.4 | 0 | 0.001 | spleen, bone marrow |
interferon regulator factor 8; response to interferon gamma |
| C1qc | 3.0 | 0 | 0.001 | macrophages | complement component 1, q subcomponent, C chain. |
| C1qa | 3.0 | 0 | 0.005 | macrophages | complement component 1, q subcomponent, alpha polypeptide |
| Cd68 | 3.0 | 0 | 0.002 | macrophages | macrophages, monocytes marker (Holness and Simmons 1993) |
| Fcgr3 | 2.9 | 0 | 0.001 | hematopoietic stem cells |
Fc receptor, IgG, low affinity III; lymphocytes activation; B-cell meditated immunity |
| Ptpn6 | 2.9 | 0 | 0.0002 | mast cells, | N/A |
| Cd14 | 2.8 | 0 | 0.001 | macrophages | macrophages, monocytes, dendritic cells |
| C1qb | 2.8 | 0 | 0.002 | striatum, macrophages |
complement component 1, q subcomponent, beta polypeptide; complement activation |
| Laptm5 | 2.8 | 0 | 0.001 | mast cells | N/A |
| Fyb | 2.4 | 0 | 0.001 | macrophages, T- cells |
N/A |
| Lyz2 | 2.3 | 0 | 0.001 | bone marrow macrophages |
N/A |
| Cyba | 2.2 | 0 | 0.001 | macrophages | N/A |
| Inpp5d | 2.1 | 0 | 0.003 | macrophages, T- cells |
N/A |
| Tnfaip8l2 | 2.0 | 0 | 0.006 | spinal cord | tumor necrosis factor alpha-induced protein 8- like protein 2 |
| Csf1r | 2.0 | 0 | 0.003 | macrophages | N/A |
| Emr1 | 1.9 | 0 | 0.02 | brain | macrophages activation |
| Rnase4 | 1.8 | 8.2 | 0.6 | N/A | microglia |
| Fermt3 | 1.7 | 0 | 0.003 | hematopoietic stem cell |
N/A |
| Ptpn18 | 1.7 | 1.2 | 0.08 | mast cells | N/A |
| P2ry13 | 1.5 | 2.6 | 0.09 | hippocampus, hypothalamus |
microglia |
| Fes | 1.5 | 0 | 0.008 | mast cells, spleen |
N/A |