Table 3.

The summary of regressions between MR-based water measurement and mechanical properties reported in the literature. Tabulated values are R² values obtained by regression analysis.

		Toughness (T), Resilience (R) or Post-yield toughness (P)	Strength or ultimate (peak) stress	Modulus	Sample size	References
Gravimetric analysis	Total water	~ 0.76 (T)+	~ 0.43+	~ 0.42+	N=36	(4)
Gravimetric analysis	Total water	0.40 (T)	0.33	−0.39	N=28	Present study
	Bound water	0.85 (T), 0.92 (P)	0.53	NS
	Unbound water	NS	−0.24	−0.54
Raman Spectroscopy	Collagen-bound water	0.81 (T), 0.73 (P)	0.51	NS	N=28	Present study
	Mineral-bound water	NS	0.48	−0.78
	Total water	0.37 (T), 0.32 (P)	0.47	0.48
	Collagen-bound water#	0.52 (T), 0.44 (P)	0.32	NS
	Mineral-bound water#	NS	0.50	0.44
NMR	Bound water	~ 0.40 (T)	~ 0.36	NS	N=18	(6)
	Unbound water	NS	~ −0.21	~ −0.25
NMR	Bound water	0.57 (R)	0.68	0.48	N=40	(9)
	Unbound water or Lipid	−0.49 (R)	−0.61	−0.49
	Total water	NS	NS	NS
MRI	Bound water*	0.30 (T)	−0.22	NA	N=44	(7)
	Unbound water*	0.17 (T)	0.14	NA
	Total water	−0.10 (T)	0.25	NA

⁺mechanical properties were measured from dried bone samples.

^#calculated from porosity adjusted Raman intensities of wet bones.

^*assigned based on T2 relaxation time: Short T2= bound water, Long T2 = unbound water, NS=not significant and NA=not applicable.

Negative values indicate inverse correlation.