Table 4.

Association between severity of abdominal aortic calcification (AAC) and the risk of non-vertebral fracture (including hip fracture) in elderly women from the SOF study

	Adjusted for age	Adjusted for age, BMI, regular walking, smoking habits, HRT, prevalent vertebral fracture, systolic blood pressure	Adjusted for age, BMI, regular walking, smoking habits, HRT, prevalent vertebral fracture, systolic blood pressure and total hip BMD	Adjusted for age, BMI, regular walking, smoking habits, HRT, prevalent vertebral fracture, systolic blood pressure, hip BMD and prior falls in past year	Adjusted for age, BMI, regular walking, smoking habits, HRT, prevalent vertebral fracture, systolic blood pressure, hip BMD prior falls in past year, and diabetes mellitus
	HR (95%CI)	HR (95%CI)	HR (95%CI)	HR (95%CI)	HR (95%CI)
5-year follow-up	n/N = 147/884	n/N = 144/869	n/N = 122/736	n/N = 121/734	n/N = 121/610
AAC score#	1.01 (0.97 – 1.05)	1.00 (0.96 – 1.04)	0.99 (0.95 – 1.04)	0.99 (0.94 – 1.04)	0.99 (0.94 – 1.04)
AAC score = 0	1.00	1.00	1.00	1.00	1.00
AAC score = 1–4	1.44 (0.98 – 2.12)	1.32 (0.88 – 1.98)	1.23 (0.79 – 1.93)	1.24 (0.79 – 1.94)	1.25 (0.80 – 1.95)
AAC score = 5+	1.22 (0.81 – 1.84)	1.12 (0.73 – 1.72)	1.00 (0.62 – 1.60)	0.97 (0.61 – 1.56)	0.95 (0.59 – 1.52)
p for trend	0.26	0.54	0.96	0.97	0.89
15-year follow-up	n/N = 388/884	n/N = 384/869	n/N = 338/736	n/N = 337/734	n/N = 336/731
AAC score#	0.99 (0.97 – 1.02)	0.99 (0.96 – 1.02)	0.98 (0.95 – 1.01)	0.98 (0.95 – 1.01)	0.98 (0.95 – 1.01)
AAC score = 0	1.00	1.00	1.00	1.00	1.00
AAC score = 1–4	1.16 (0.92 – 1.48)	1.13 (0.88 – 1.45)	1.05 (0.80 – 1.37)	1.07 (0.82 – 1.41)	1.09 (0.83 – 1.43)
AAC score = 5+	1.07 (0.83 – 1.38)	1.03 (0.79 – 1.34)	0.98 (0.74 – 1.30)	0.99 (0.74 – 1.31)	0.98 (0.74 – 1.30)
p for trend	0.50	0.73	0.94	0.99	0.96

^#per 1 unit increase;

BMI – body mass index, BMD – bone mineral density, HRT – hormone replacement therapy n - number of women with fractures in the analysis, N – total number of women in the analysis