Figure 4. PTZ-evoked PSDs and GTCs in Het_α1KO and Het_α1AD mice at P35 and P120.

PTZ-evoked PSDs from Het_α1KO (KO, A, C) and Het_α1AD mice (AD, B, D) show a similar morphology to spontaneous PSDs (Fig 3). Depiction on an expanded time scale (C, D) reveals that the PTZ-evoked PSDs are composed of irregular spikes (S) positive transients (Pt), and waves (W). There is no significant difference (E, P ≥ 0.103) in PTZ-evoked PSD among wild type (1.51 ± 0.61 PSD/hr, N = 9), Het_α1KO (6.95 ± 3.14 PSD/hr, N = 10), and Het_α1AD (2.64 ± 0.79 PSD/hr, N = 13). The P120 mice had a significantly higher PSD frequency (6.3 ± 1.8 PSD/hr, N = 17, P = 0.006) than P35 mice (0.69 ± 0.26 PSD/hr, N = 15). Genotype did alter the PSD latency relative to the time from first PTZ injection (F) with Het_α1KO mice (dashed line) and Het_α1AD mice (dotted line) having shorter PSD latencies than wild type mice (solid line, P < 0.001). G) The probability of a PTZ-evoked GTC was greater in P120 mice (0.588, P = 0.002) was greater than in P35 mice (0.067), but there was no significant effect of genotype on PTZ-evoked GTCs. ns = nonsignificant, ** = P < 0.01