Table 1. Histomorphometry: Cortical bone.
WT | PAPP-A KO | |||
---|---|---|---|---|
Vehicle | PTH (%Δ) | Vehicle | PTH (%Δ) | |
BV/TV (%) | 4.43 ± .060 | 4.76 ± 0.241 (+7) | 4.36 ± 1.46 | 4.45 ± 0.265 (+2) |
MS/BS (%) | 17.2 ± 3.97 | 18.8 ± 4.79 (+9) | 20.8 ± 1.50 | 20.0 ± 1.52 (-4) |
BFR/BS (μm3/ μm2/d) | 0.20 ± 0.035 | 0.27 ± 0.044 (+35) | 0.25 ± 0.009 | 0.23 ± 0.016 (-8) |
BFR/BV (%/d) | 1.20 ± 0.201 | 1.90 ± 0.047* (+60) | 1.90 ± 0.015 | 1.68 ± 0.212 (-12) |
MAR (μm/d) | 0.98 ± 0.015 | 1.50 ± 0.165* (+53) | 1.22 ± 0.130 | 1.15 ± 0.078 (-6) |
Results are presented as mean ± SEM of 3-4 mice per treatment group. Percent change with PTH compared to vehicle treatment is in parentheses.
Significant effect of PTH, P < 0.05
BV, bone volume
TV, total volume
BS, bone surface
MS, mineralizing surface
BFR, bone formation rate
MAR, mineral apposition rate