Table 3.
Zebrafish animal models of liver disease and hepatocellular carcinoma
| Transgene name | Expression system | Liver pathology | Ref. |
| cnr1 (Zebrafish) | Tet-off-inducible | Steatosis | [132] |
| edn1 (Zebrafish) | Constitutive | Steatosis, bile duct dilation, hyperplasia and HCC | [69] |
| gankyrin (Zebrafish) | Constitutive | Atrophy, hypoplasia and steatosis | [123] |
| HBx (Human) | Constitutive | Hypoplasia and steatosis | [120] |
| HBx + AFB1 (Human) | Constitutive | Hepatitis, steatosis and hyperplasia | [134] |
| HBx + HCV (Human) | Tet-off-inducible | Intrahepatic cholangiocarcinoma | [81] |
| HBx + p53M214 (Human) | Constitutive | Chronic inflammation, steatosis, bile duct dilation, dysplasia and HCC | [70] |
| HBx + src (Human/Zebrafish) | Constitutive | Chronic inflammation, steatosis, bile duct dilation, dysplasia and HCC | [70] |
| HCV (Human) | Constitutive | Steatosis | [29] |
| HCV + TAA (Human) | Constitutive | Steatosis and HCC | [29] |
| kras-G12V (Zebrafish) | Mifepristone | Hyperplasia and HCC | [82] |
| kras-G12V (Zebrafish) | Constitutive | Hyperplasia and hepatocellular adenoma | [82] |
| kras-G12V (Zebrafish) | Tet-on-inducible | Hyperplasia, hepatocellular adenoma and HCC | [137] |
| kras-G12V + p53M214 (Zebrafish) | Constitutive | Hyperplasia and hepatocellular adenoma | [82] |
| kras-G12V + RhoA (Zebrafish) | Tet-on-inducible | Hyperplasia, hepatocellular adenoma and HCC | [137] |
| kras-G12V + RhoAG14V (Zebrafish) | Tet-on-inducible | Hyperplasia, hepatocellular adenoma and HCC | [137] |
| kras-G12V + RhoAT19N (Zebrafish) | Tet-on-inducible | HCC | [137] |
| Lc3 (Rat) | Constitutive | Investigation of liver autophagy | [141] |
| mdm2 (Zebrafish) | Constitutive | Atrophy, contraction and hypoplasia | [121] |
| MYC (Mouse) | Tet-on-inducible | Hyperplasia and hepatocellular adenoma | [83] |
| myca (Zebrafish) | Mifepristone | Small, typical, hypervascular and ascites of liver tumor | [143] |
| myca + p53M214 (Zebrafish) | Mifepristone | Small, typical, hypervascular and ascites of liver tumor | [143] |
| mycb (Zebrafish) | Mifepristone | Small, typical, hypervascular and ascites of liver tumor | [143] |
| orf A (Human) | GAL4/UAS | Delayed onset of liver tumor | [79] |
| src (Zebrafish) | Constitutive | Chronic inflammation, steatosis, bile duct dilation, hyperplasia, dysplasia and HCC | [70] |
| src + p53M214 (Zebrafish) | Constitutive | Steatosis, hyperplasia, dysplasia and HCC | [70] |
| UHRF1 (Human) | Constitutive | Atypical cells, dysplastic foci and HCC | [124] |
| UHRF1 + p53M214 (Human) | Constitutive | Atypical cells, dysplastic foci and HCC | [124] |
| xmrk (Xiphophorus) | Tet-on-inducible | Hyperplasia, hepatocellular adenoma and HCC | [80] |
| yy1 (Zebrafish) | Constitutive | Steatosis | [131] |
| zfBLP1 (Zebrafish) | Constitutive | Hyperplasia | [133] |
| zfMcl-1α (Zebrafish) | Constitutive | Hyperplasia | [133] |
HCC: Hepatocellular carcinoma; HBx: Hepatitis B virus X protein; HCV: Hepatitis C virus.