Milan |
1 tumor < 5 cm in diameter or |
Mazzaferro et al[7] |
≤ 3 tumor nodules, each ≤ 3 cm in diameter |
No extrahepatic manifestation |
No vascular invasion |
Up-to-seven criteria (“new Milan”) |
Seven as the sum of the size of the largest tumor (in cm) and the number of tumors |
Mazzaferro et al[166] |
Kyoto |
≤ 10 tumors, all ≤ 5 cm in diameter |
Takada et al[167] |
PIVKA-II > 400 mAU/mL |
UCSF |
Solitary tumor ≤ 6.5 cm or |
Yao et al[9] |
≤ 3 nodules with largest lesion ≤ 4.5 cm and total tumor diameter ≤ 8 cm |
No gross vascular invasion |
Shanghai Fudan |
Solitary tumor ≤ 9 cm in diameter or |
Fan et al[168] |
≤ 3 lesions with the largest ≤ 5 cm and total tumor diameter ≤ 9 cm |
Hangzhou |
Total tumor diameter ≤ 8 cm or |
Zheng et al[169] |
Total tumor diameter more than 8 cm with histopathological grade I or II and preoperative α-fetoprotein ≤ 400 ng/mL |
Lee et al[170] |
Asan |
Largest tumor diameter ≤ 5 cm |
Hepatocellular carcinoma number ≤ 6 |
No gross vascular invasion |