Table 1.
Chronic liver failure-sequential organ failure assessment score
| Organ failure | 0 | 1 | 2 | 3 | 4 |
| Liver (Tbil, mg/L) | < 1.2 | ≥ 1.2 to < 2.0 | ≥ 2.0 to < 6.0 | ≥ 6.0 to < 12 | ≥ 12.0 |
| Kidney (cr, mg/dL) | < 1.2 | ≥ 1.2 to < 2.0 | ≥ 2.0 to < 3.5 | ≥ 6.0 to < 12 | ≥ 5.0 |
| Or use of renal replacement therapy | |||||
| Cerebral (HE grade) | No HE | I | II | III | IV |
| Coagulation (INR) | < 1.1 | ≥ 1.1 to < 1.25 | ≥ 1.25 to < 1.5 | ≥ 1.5 to < 2.5 | ≥ 2.5 or PLT ≤ 20 × 109/L |
| Circulation (MAP, mmHg) | ≥ 70 | < 70 | DA ≤ 5 or DOB or Terlipressin | DA > 5 or E ≤ 0.1 or NE ≤ 0.1 | DA > 15 or E 0.1 or NE > 0.1 |
| Lung PaO2/FiO2 | > 400 | > 300 to ≤ 400 | > 200 to ≤ 300 | > 100 to ≤ 200 | ≤ 100 |
| Or SpO2/FiO2 | > 512 | > 357 to ≤ 512 | > 214 to ≤ 357 | > 89 to ≤ 214 | ≤ 89 |
This score is used to categorize patients into grades of ACLF. ACLF: Acute-on-chronic liver failure; CLIF: Chronic liver failure; SOFA: Sequential organ failure assessment; Tbil: Total bilirubin; cr: Serum creatinine; HE: Encephalopathy; INR: International normalized ratio; PLT: Plateletes; DA: Dopamine; DOB: Dobutamine; E: Epinephrine; NE: Norepinephrine; PaO2: Partial pressure of arterial oxygen; FiO2: Fraction of inspired oxygen; SpO2: Pulse oximetry saturation. Data from Moreau et al[12].