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Grades of acute-on-chronic liver failure according to the number of organ failure and the type of organ
| No. ACLF | |
| ACLF grade 1 | Single- organ failure (coagulation, liver, circulation, lungs) in patients with sCr 1.5-1.9 mg/dL and/or grades 1-2 HE or braine failure with sCr range from 1.5-1.9 mg/dL |
| ACLF grade 2 | Two organ failures |
| ACLF grade 3 | Three or more organ failures |
Data from the CANONIC study[12]. ACLF: Acute-on-chronic liver failure; OF: Organ failure.
