Table 1.
Hepatocellular carcinoma signaling pathways identified by Sleeping Beauty transposon insertional mutagenesis system[63,66]
| Pathways | Wnt/Ctnnb1 | Trp53 | Pi3k-Akt-Mtor | Mapk | Hippo | Tgfb-Bmp | Il6-Stat3 | Tnf-Akt1 |
| Genes involved in corresponding pathways | Lrp1 | Prkag2 | Insr | Egfr | Fat1 | Acvr1 | Il6st (gp130) | Tnf |
| Lrp5 | Ywhaz | Igf1 | Met | Wwc1 | Acvr2a | Jak1 | Egfr | |
| Lrp6 | Crebbp | Pten | Grb2 | Taok1 | Bmp1 | Stat3 | Met | |
| Gsk3b | Mdm2 | Pik3ca | Sos1 | Taok2 | Bmpr1a | Pak4 | ||
| Axin1 | Usp10 | Pik3r1 | Sos2 | Taok3 | Sar1a | Nfib | ||
| Apc | Usp7 | Pik3c2a | Kras | Mobkl2b | Tab2 | Taok3 | ||
| Ctnnb1 | Pias1 | Pik3ap1 | Raf1 | Mobkl1a | Tab3 | Map2k4 | ||
| Tcf7l2 | Trp53inp1 | Akt2 | Map3k1 | Sav1 | Smad3 | Akt | ||
| Csnk1a1 | Ppp2r1a | Rps6kb1 | Map3k2 | Lats1 | Smad2 | Hif1a | ||
| Csnk1d | Ppp2r2a | Foxo1 | Map2k1 | Yap1 | Smad1 | Ube2h | ||
| Csnk1g1 | Ppp2r2d | Mapk1 | Tead1 | Smad4 | Qk | |||
| Csnk1g3 | Ppp2cb | Smad5 | Pi3k | |||||
| Tnks | Ppp2r5e | Jnk | ||||||
| Tnks2 | Trp53 |
1
Indicates a network.