Table 2.
Subjects' characteristics according to the apolipoprotein E genotype.
| ApoE 2/4 (A) |
ApoE 2/2 (B) |
ApoE 2/3 (C) |
ApoE 3/3 (D) |
ApoE 3/4 (E) |
ApoE 4/4 (F) |
p value | |
|---|---|---|---|---|---|---|---|
| Men/women | 51/53 | 48/46 | 326/330 | 660/625 | 247/239 | 24/31 | NS |
| Age (years) | 48.8 ± 12.7 | 50.8 ± 13.07 | 50.3 ± 11.2 | 48.8 ± 12.1 | 48.8 ± 11.9 | 46.2 ± 11.3 | NS |
| Waist circumference (cm) | 88.2 ± 13.2 | 90.7 ± 12.3 | 90.5 ± 13.3 | 89.8 ± 13.9 | 88.5 ± 13.1 | 86.6 ± 12.6 | 0.056 |
| BMI (kg/m2) | 26.6 ± 4.3 | 27.3 ± 4.3 | 26.9 ± 4.6 | 26.6 ± 4.5 | 26.5 ± 4.4 | 25.8 ± 4.3 | 0.082 |
| Smoking habits1 (%) | 66.3 | 61.7 | 68.4 | 65.4 | 67.3 | 58.2 | NS |
| Type 2 diabetes1 (%) | 10.6 | 11.7 | 14.5 | 14.7 | 14.4 | 9.1 | NS |
| Hypertension1 (%) | 42.3 | 38.3 | 39.6 | 37.1 | 41.2 | 30.9 | NS |
| CAD (%) | 29.8 | 28.7 | 27.9 | 28.4 | 24.5 | 27.3 | NS |
| Triglycerides (mmol/L)∗,† | 2.06 ± 1.95 | 2.97 ± 3.26a | 1.88 ± 2.02b | 1.60 ± 1.99a,b,c | 1.81 ± 2.18b,d | 2.20 ± 3.46 | <0.001 |
| Total cholesterol (mmol/L)† | 5.52 ± 1.34 | 6.50 ± 3.16 | 5.37 ± 1.35b | 5.41 ± 1.05b | 5.64 ± 1.18b,c,d | 6.02 ± 1.11c,d | <0.001 |
| LDL-cholesterol (mmol/L)† | 3.17 ± 0.89 | 2.66 ± 1.08 | 2.96 ± 0.90 | 3.27 ± 0.83b,c | 3.37 ± 0.82b,c | 3.40 ± 0.85b,c | <0.001 |
| HDL-cholesterol (mmol/L) | 1.17 ± 0.44 | 1.13 ± 0.55 | 1.21 ± 0.44 | 1.22 ± 0.41 | 1.20 ± 0.42 | 1.14 ± 0.42 | NS |
| Total ApoB (g/L)§,† | 1.05 ± 0.24 | 0.83 ± 0.32a | 1.00 ± 0.26b | 1.06 ± 0.24b,c | 1.12 ± 0.25b,c,d | 1.20 ± 0.27b,c,d | <0.001 |
Data are mean ± S.D.
Note: ApoB: apolipoprotein B-100 measured on delipidated plasma; BMI: body mass index; CAD: coronary artery disease; HDL: high-density lipoprotein; LDL: low-density lipoprotein.
1Proportion (%) of individuals who ever smoked (smoking habits), are diabetic (type 2 diabetes), and are hypertensive.
§Among a subsample of 1,915 subjects.
Significantly different (p < 0.05) as compared to a E2/4; to bE2/2; to cE2/3; to dE3/3.
∗ p value obtained after log10 transformation of the data; geometric means are shown.
†Kruskal-Wallis tests followed by Mann-Whitney U tests; geometric means are shown.
NS = p > 0.05.