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. 2015 Oct 28;2015:503079. doi: 10.1155/2015/503079

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Copyright © 2015 R. Brunkhorst et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Expression of ceramide-metabolizing enzymes is differentially regulated in the peri-infarct cortex. (a) ASM mRNA, (b) neutral sphingomyelinase- (NSM-) 2 mRNA, (c) NSM-1 mRNA, (d) Acid ceramidase (ACER) mRNA, (e) neutral ceramidase (NCER) mRNA, (f) glucocerebrosidase- (GBA-) 1 mRNA, (g) GBA-2 mRNA, and (h)–(l) CerS1–6 mRNA, mRNA-levels were measured at the indicated time points by Taqman-PCR. Differences between sham and PT group were analyzed using Student's unpaired two-tailed t-test. Data are presented as means ± SD; sham values are indicated by dotted line (for individual sham-SD's, see Section 3); values are not significantly different compared to sham if not marked otherwise; ^∗ p ≤ 0.05; ^∗∗ p ≤ 0.01; n.s., nonsignificant; n = 8–10/group.