TABLE I.
Differential Expression of Cytokines in Human Neuroprogenitor Cell (hNPC) and During Oligodendrocyte Lineage Progression*
| Cytokine/chemokine | hNPC | hOPC | hOL(early) | hOL(late) |
|---|---|---|---|---|
| CCL1/I-309 | 4.0±0.7 | 10.0±0.17 | 11.2±0.09 | 12.9±0.35 |
| CCL2/MCP-1 | 6.0±0.006 | 109.3±3.3 | 83.7±0.2 | 73.7±0.5 |
| CCL3/MIP-1α | 9.0±0.4 | 4.8±1.6 | 3.1±0.1 | 3.3±1.37 |
| CCL4/MIP-1β | 10.0±0.48 | 20.6±1.0 | 22.7±0.86 | 22.1±3.6 |
| CCL5/RANTES | 12.0±2.0 | 11.5±2.7 | 17.2±0.6 | 12.7±1.77 |
| CCL13/MCP-4 | 7.0±0.7 | 0.0 | 0.3±0.67 | 0.1±0.2 |
| CCL17/TARC | 12.0±0.9 | 5.7±1.6 | 5.2±0.67 | 2.7±0.65 |
| CCL22/MDC | 8.0±4.4 | 7.5±0.06 | 5.3±0.5 | 4.7±0.4 |
| CCL26/eotaxin-3 | 1.0±1.3 | 10.4±1.6 | 9.9±2.2 | 6.0±1.2 |
| CCL27/CTACK | 1.9±0.5 | 13.6±0.8 | 16.1±2.1 | 15.1±1.8 |
| GRO | 102.3±0.8 | 66.2±6.06 | 62.5±0.78 | 18.1±1.89 |
| CXCL1/GROα | 49.3±2.9 | 4.8±1.8 | 2.0±0.7 | 1.0±0.2 |
| CXCL5/ENA-78 | 9.9±1.6 | 7.3±1.7 | 8.2±0.5 | 5.5±1.4 |
| CXCL6/GCP-2 | 3.0±1.8 | 7.7±1.8 | 8.5±1.0 | 6.1±2.7 |
| CXCL7/NAP2 | 11.0±3.78 | 18.2±0.99 | 21.8±0.97 | 19.6±3.0 |
| CXCL8/IL-8 | 18.6±0.7 | 14.7±1.3 | 15.2±1.6 | 12.1±0.5 |
| CXCL10/IP-10 | 12.3±2.2 | 13.8±2.78 | 25.3±2.0 | 14.2±3.0 |
| CXCL16 | 0.0 | 14.5±1.9 | 16.9±1.2 | 8.0±1.8 |
| XCL1/lymphoactin | 5.0±0.17 | 10.4±1.2 | 7.0±1.6 | 7.2±1.6 |
| CX3CL1/fractalkine | 2.0±2.29 | 4.5±0.9 | 4.03±1.4 | 2.5±1.25 |
*
The intensities of signals corresponding to each cytokine/chemokine were analyzed in NIH Image, normalized to background and positive controls, and presented as optic density units.