Table 4.

Lean mass index and fat mass index within mutually adjusted model, regressed on HRpQCT outcomes by sex with adjustment for covariates^*.

		Lean mass index				Fat mass index
		Men		Women		Men		Women
		Beta (95% CI)	p-value	Beta (95% CI)	p-value	Beta (95% CI)	p-value	Beta (95% CI)	p-value
Total area (mm2)	R	8.45 (−1.29,18.19)	0.089	3.99 (−1.45,9.43)	0.149	−6.20 (−11.42,−0.98)	0.020	0.54 (−1.79,2.87)	0.645
	T	12.10 (−5.55,29.75)	0.178	2.50 (−9.72,14.71)	0.687	−7.70 (−17.12,1.73)	0.109	1.65 (−3.64,6.94)	0.538
Cortical area (mm2)	R	2.77 (1.10,4.44)	0.001	1.10 (0.06,2.14)	0.038	0.15 (−0.74,1.05)	0.741	0.24 (−0.21,0.68)	0.291
	T	6.99 (3.97,10.01)	<0.001	3.59 (1.81,5.38)	<0.001	1.30 (−0.31,2.91)	0.114	0.78 (0.01,1.55)	0.048
Cortical thickness (μm)	R	27.92 (4.39,51.45)	0.020	7.08 (−13.87,28.02)	0.505	6.75 (−5.85,19.36)	0.292	1.87 (−7.10,10.84)	0.680
	T	51.30 (21.61,80.99)	0.001	29.59 (7.12,52.06)	0.010	12.08 (−3.77,27.93)	0.134	3.09 (−6.64,12.83)	0.531
Cortical density (mg/cm3)	R	3.32 (−2.70,9.34)	0.278	−3.47 (−10.94,3.99)	0.360	−1.41 (−4.63,1.82)	0.390	0.22 (−2.97,3.42)	0.890
	T	4.50 (−2.75,11.75)	0.222	3.41 (−4.45,11.27)	0.392	−0.28 (−4.15,3.59)	0.887	2.70 (−0.71,6.10)	0.120
Cortical porosity (%)	R	0.02 (−0.15,0.19)	0.798	0.08 (−0.10,0.26)	0.362	0.07 (−0.02,0.16)	0.152	−0.02 (−0.09,0.06)	0.680
	T	0.01 (−0.29,0.31)	0.940	0.02 (−0.32,0.35)	0.929	0.10 (−0.06,0.26)	0.202	0.01 (−0.13,0.16)	0.851
Trabecular area (mm2)	R	5.86 (−3.46,15.17)	0.216	2.95 (−2.69,8.58)	0.303	−5.37 (−10.37,−0.38)	0.035	0.47 (−1.94,2.89)	0.699
	T	4.85 (−13.21,22.90)	0.597	−0.84 (−13.79,12.12)	0.899	−9.70 (−19.34,−0.06)	0.049	1.06 (−4.55,6.67)	0.710
Trabecular density (mg/cm3)	R	0.77 (−3.75,5.30)	0.736	0.80 (−4.38,5.97)	0.762	1.63 (−0.79,4.06)	0.186	2.01 (−0.21,4.23)	0.075
	T	0.22 (−3.94,4.38)	0.917	−0.39 (−5.28,4.49)	0.874	2.46 (0.23,4.68)	0.030	1.59 (−0.52,3.70)	0.139
Trabecular number (cm−1)	R	0.12 (−0.18,0.42)	0.437	0.08 (−0.42,0.57)	0.760	0.16 (0.00,0.32)	0.048	0.27 (0.06,0.49)	0.011
	T	0.28 (−0.04,0.60)	0.089	0.27 (−0.15,0.68)	0.208	0.38 (0.21,0.56)	<0.001	0.28 (0.10,0.46)	0.002
Trabecular thickness (μm)	R	−0.08 (−1.34,1.18)	0.905	0.01 (−1.31,1.33)	0.986	0.14 (−0.53,0.82)	0.674	−0.00 (−0.57,0.56)	0.987
	T	−0.71 (−1.88,0.46)	0.232	−0.69 (−2.17,0.79)	0.357	−0.13 (−0.75,0.50)	0.693	−0.23 (−0.87,0.41)	0.477
Trabecular separation (μm)	R	−3.76 (−11.48,3.97)	0.338	−0.43 (−18.13,17.26)	0.961	−2.68 (−6.81,1.46)	0.203	−7.34 (−14.92,0.24)	0.057
	T	−3.51 (−9.61,2.59)	0.258	−6.17 (−16.66,4.31)	0.246	−6.09 (−9.34,−2.83)	<0.001	−5.09 (−9.63,−0.55)	0.028

Key: In bold if p<0.05. R, radius; T, tibia.

^*Covariates are age at HRpQCT scan, smoking status, alcohol consumption, calcium intake, vitamin D intake, physical activity and social class; with additional adjustment for years since menopause and HRT use in women