Scheme 7.
Reagents and conditions: (a) (i) SOCl2, dioxane, reflux, 12 h, (ii) NaBH4, THF, 0 °C, 0.5 h then rt, 12 h; (b) PBr3, DCM, 0 °C then rt, 1 h; (c) NaCN, TBAB, H2O/DCM (1:1), rt, 5 days; (d) AcOH, H2SO4, H2O, 118 °C, 3 h.
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