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. 2015 Nov 10;6:220. doi: 10.1186/s13287-015-0213-z

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© Xu et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Sim1-Puro cultures exhibit synaptic marker protein and mRNA expression after 2 weeks. a–f Two-week selected cultures stained with dendritic marker MAP2 and synaptic markers, SV2 and Bassoon. Synaptic markers (b and e, red) exhibit puncta that overlap with MAP2 (c and f, white arrows) suggesting synapse formation. Scale bar = 50 μm. g Two-week selected cultures express increased synaptic marker (Bassoon, PSD95, and SV2) and VGluT2 (glutamatergic neuron) mRNA levels compared to unselected cultures (normalization control – Sim1-Puro ESCs). * Denotes P <0.05 compared to the unselected group