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. 2015 Nov 10;15:888. doi: 10.1186/s12885-015-1875-8

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© Yoon et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Effects of SOX4 knockdown (SOX4-KO) on cell invasion and migration in head and neck squamous cell carcinoma cells. a In the cell invasion assay, significantly fewer SOX4-KO PCI50 and SNU1041 cells invaded than did negative control cells. Stained invading cells were counted (bar graph; mean ± SE, experiments were run in triplicate; ^*P < 0.05). b Cell migration was significantly less in SOX4-KO PCI50 and SNU1041 cells than in negative control cells (displayed as relative healing distances measured in three random sites). Values indicate mean ± SE for three independent experiments (^*P < 0.05). C: negative control siRNA transfected cells; S: SOX4-specific siRNA transfected cells (SOX4-KO)