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. 2015 Sep 21;16(11):1511–1519. doi: 10.15252/embr.201540982

Figure 4. Impairment of carotid body postnatal maturation with maintenance of adult stem cells in hGFAP-SDHD mice.

Figure 4

  • A Immunofluorescence detection of TH expression in newborn (P0) and P15 wild-type (control) and hGFAP-SDHD mouse carotid body (CB). Boundaries of the CB parenchyma are indicated by the dotted lines. Scale bar: 50 μm.
  • B, C Number of TH+ cells (B) and size (C) per CB at different ages in control and hGFAP-SDHD mice. Data are presented as mean ± SEM (n = 3–5 mice in each group). *P ≤ 0.05; **P ≤ 0.01. The two-tailed Student’s t-test was applied.
  • D Bright-field images of CB neurospheres obtained from control and mutant mice at P15. Scale bar: 200 μm.
  • E, F Neurosphere forming efficiency (E) and diameter (F) of floating cultures of dispersed CB cells from P15 control and hGFAP-SDHD mice. Data are presented as mean ± SEM (n = 6 cultures/mice for each genotype).