Figure 6. Best policy over parameters in the population-level model.
Light blue corresponds to Spearman correlation greater than 0.7, dark corresponds to less than −0.7 and mid-range blue corresponds to all values in between. An aggressive policy is best when the DR strain is relatively unfit (low R0 value; left panel). When the acquisition rate is high, treatment-driven reductions in DS decrease the DR prevalence (second panel). When the two strains are more independent (low similarity coefficient), competition is reduced, so that reductions in the DS strain do not much benefit the DR strain, leading to the aggressive policy being preferred (third panel). When R01 is high, a moderate outcome results, because inter-strain competition is more effective. Vertical axes (‘count’) are the fraction of simulations in each category.