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. Author manuscript; available in PMC: 2015 Nov 11.
Published in final edited form as: J Neurooncol. 2014 Dec 18;123(3):395–403. doi: 10.1007/s11060-014-1687-8

Fig. 1.

Fig. 1

Glioma-derived IDO1 plays a critical role in immune-mediated suppression in an experimental orthotopic brain tumor model. The in vivo role of IDO1 was investigated using the intracranially-injected GL261 model of malignant glioma. a The peripheral (i.e. any non-tumor cell) absence of IDO1 neither affected Treg levels in the brain tumor nor overall survival. b The genetic absence of brain tumor-derived IDO1 significantly decreased Treg levels in the brain tumor and increased overall survival. When brain tumors were deficient for IDO1, but competent in the periphery, Treg levels were normal in the draining cervical lymph nodes (cLN). In contrast, when mice were co-deficient for IDO1, both in the brain tumor and periphery, Treg levels were significantly decreased in the cLN, suggesting a level of communication between the central (tumor) and peripheral (cLN) compartments related to the expression of IDO1