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. 2015 Nov 11;10(11):e0142425. doi: 10.1371/journal.pone.0142425

Table 2. Drug susceptibility testing results for multidrug resistant tuberculosis patients in Estonia, Latvia and Romania in 2013.

Estonia Latvia Romania
New cases Retreatment cases New cases Retreatment cases New cases Retreatment cases
# (%) # (%) # (%) # (%) # (%) # (%)
Total 29 21 50 26 165 410
  Number undergoing 1st line DST 29 (100.0) 21 (100.0) 50 (100.0) 26 (100.0) 165 (100.0) 410 (100.0)
    Additional resistance to…
              Ethambutol 27 (96.4) a 20 (95.2) 36 (72.0) 21 (80.8) 68 (70.1) b 195 (76.5) b
              Pyrazinamide 20 (71.4) a 15 (71.4) 36 (75.0) c 18 (69.2) Not tested Not tested
  Number undergoing 2nd line DST 28 (96.6) 21 (100.0) 50 (100.0) 26 (100.0) 108 (65.5) 276 (67.3)
    Additional resistance to…
              Amikacin 3 (10.7) 3 (14.3) 22 (44.0) 9 (34.6) 9 (13.6) b 51 (33.1) b
              Capreomycin 3 (10.7) 3 (14.3) 25 (50.0) 15 (57.7) 13 (18.6) b 61 (37.2) b
              Kanamycin 5 (17.9) 9 (42.9) 21 (42.9) d 15 (57.7) 18 (20.7) b 94 (40.2) b
              Ofloxacin 10 (35.7) 9 (42.9) 9 (18.0) 8 (30.8) 13 (18.8) b 48 (31.6) b
              Moxifloxacin 2 (10.5) e 2 (16.7) e Not tested Not tested Not tested Not tested
              Cycloserine Not tested Not tested 1 (2.0) 0 (0.0) 2 (7.1) b 17 (16.2) b
              PAS Not tested Not tested 12 (25.0) c 5 (19.2) 5 (8.3) b 14 (9.3) b
              Prothionamide 4 (14.3) 9 (42.9) 26 (52.0) f 19 (73.1) f 10 (11.2) f 27 (12.3) f
              Linezolid 0 (0.0) g 2 (14.3) g Not tested Not tested Not tested Not tested

aDenominator 28

bdenominators (new cases, retreatment cases) ethambutol 97, 255; amikacin 66, 154; capreomycin 70, 164; kanamycin 87, 234; ofloxacin 69, 152; cycloserine 28, 105; PAS 60, 151

cdenominator 48

ddenominator 49

edenominator 19 new, 12 retreatment

fethionamide DST undertaken in Latvia and Romania (denominators for new Romanian cases 89, retreatment cases 220)

gdenominator 21 new, 14 retreatment. DST- drug susceptibility testing; PAS- p-aminosalicylic acid.