Table 3. Association of polymorphism FAAH 385C>A with AEA, OEA and HMW adiponectin levels.
Whole group | Eutrophics | Obeses | |||||||
---|---|---|---|---|---|---|---|---|---|
Variables | AA | CC+CA | P | AA | CC+CA | P | AA | CC+CA | P |
(n = 14) | (n = 186) | value | (n = 5) | (n = 95) | value | (n = 9) | (n = 91) | value | |
AEA | 3.36 | 2.45 | 0.02 | 2.76 | 2.07 | 0.04 | 4.13 | 2.78 | 0.02 |
(pmol/mL) | (2.10, 5.05) | (1.90, 3.28) | (2.02, 2.93) | (1.73, 2.94) | (2.54, 4.97) | (2.05, 3.63) | |||
OEA | 25.67 | 20.09 | 0.12 | 17.34 | 18.21 | 0.68 | 28.51 | 22.21 | 0.02 |
(pmol/mL) | (16.81, 35,13) | (15.48, 25.08) | (13.99, 17.84) | (14.30, 22.90) | (22.93, 38.16) | (16.33, 27.99) | |||
HMW adip | 1.86 | 3.09 | 0.10 | 4.09 | 4.12 | 0.83 | 1.36 | 2.33 | 0.02 |
(μg/mL) | (1.24, 3.93) | (1.67, 4.92) | (3.88, 4.42) | (2.43, 5.72) | (1.13, 1.92) | (1.21, 3.59) |
Values are medians (percentiles 25th, 75th).
P values for differences in variables levels between AA and CC + CA genotypes (Mann-Whitney test).
Variables are age- and sex-adjusted.
AEA, anandamide; OEA, N-oleoylethanolamide; HMW adip, high molecular weight adiponectin.