Table 1. Characteristics of included trials.
| First author | Year | Setting | Study drug | Control treatment | Study drug patients | Control patients | Study drug dose | Longest follow-up | Prophylactic study drug administration? | Catecholamines before study drug administration? | Use of additional catecholamines allowed? |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Albanèse J [21] | 2005 | Sepsis | Terlipressin | Norepinephrine | 10 | 10 | 1 mg bolus, further 1 mg bolus if MAP < 65 mmHg after 20 min | Hospital stay | No | No | Yes, after the six-hours study period |
| Cohn SM [22] | 2011 | Acute traumatic injury | Vasopressin | Placebo | 38 | 40 | 4 IU bolus followed by infusion of 2.4 IU/h for 5 h | 30-days | No | Not specified | Not specified |
| Dünser MW [23] | 2003 | Vasodilatory shock | Vasopressin | Standard treatment | 24 | 24 | 4 IU/h | ICU stay | No | Yes | Yes |
| Hasija S [24] | 2010 | Cardiac surgery | Vasopressin | Placebo | 15 | 32 | 0.03 IU/min during surgery | Hospital stay | Yes | N/A | Yes |
| Hua F [25] | 2013 | Sepsis | Terlipressin | Dopamine | 16 | 16 | 1.3 μg/kg/h for 48 h | 28 days | No | No | Yes |
| Kirov MY [26] | 2001 | Sepsis | Methylene blue | Placebo | 10 | 10 | 2 mg/kg bolus over 15 minutes, followed by 0.25–2 mg/kg/h continuous infusion for 4 hours | 28 days | No | Yes | Yes |
| Lauzier F [27] | 2006 | Sepsis | Vasopressin | Norepinephrine | 13 | 10 | 0.04–0.20 IU/min for 48 h | ICU stay | No | Not specified | Yes |
| Levin RL [28] | 2004 | Cardiac surgery | Methylene blue | Placebo | 28 | 28 | 1.5 mg/kg/h for 1 hour | Hospital stay | No | Yes | Yes |
| Luckner G [29] | 2006 | Vasodilatory shock | Vasopressin | Standard treatment | 10 | 8 | 4 IU/h | ICU stay | No | Yes | Yes |
| Malay MB [30] | 1999 | Sepsis | Vasopressin | Placebo | 5 | 5 | 0.04 IU/min | 24 hours | No | Yes | Yes |
| Maslow AD [31] | 2006 | Cardiac surgery | Methylene blue | Placebo | 15 | 15 | 3 mg/kg bolus | Operating theatre | Yes | N/A | Yes |
| Memis D [32] | 2002 | Sepsis | Methylene blue | Placebo | 15 | 15 | 0.5 mg/kg/h for 6 hours | Hospital stay | Not specified | Not specified | |
| Morales DL [33] | 2003 | Cardiac surgery | Vasopressin | Placebo | 17 | 16 | 0.03 IU/min for up to 72 h | Hospital stay | Yes | N/A | Yes |
| Morelli A DOBUPRESS [34] | 2008 | Sepsis | Terlipressin | Standard treatment | 20 | 20 | 1 mg bolus | ICU stay | No | Yes | Yes |
| Morelli A TERLIVAP [35] | 2009 | Sepsis | Vasopressin, terlipressin | Norepinephrine | 15+15 | 15 | 1.3 μg/kg/h (terlipressin), 0.03 IU/min (vasopressin) for 48 h | ICU stay | No | No | Yes |
| Okamoto Y [36] | 2014 | Cardiac surgery | Vasopressin | Placebo | 49 | 47 | 1.8 U/h intraoperatively until hemodynamic stability or ICU admission | 30-days | No | No | Yes |
| Özal E [37] | 2005 | Cardiac surgery | Methylene blue | Standard treatment | 50 | 50 | 2 mg/kg infusion for more than 30 minutes | Hospital stay | Yes | N/A | Yes |
| Papadopoulos G [38] | 2010 | Cardiac surgery | Vasopressin | Placebo | 25 | 25 | 0.03 IU/min from 30 minutes before CPB to 4 hours after CPB termination | Hospital stay | Yes | N/A | Yes |
| Russell JA VASST [10] | 2008 | Sepsis | Vasopressin | Norepinephrine | 405 | 395 | 0.01–0.03 IU/min | 90 days | No | Yes | Yes |
| Svoboda P [39] | 2012 | Sepsis | Terlipressin | Standard treatment | 15 | 17 | 4 mg/24 h continuous infusion for 72 h | 90 days | No | Yes | Yes |
CPB: cardiopulmonary bypass; h: hours; ICU: intensive care unit; IU: international units; MAP: mean arterial pressure.