Table 2. The effect of vitamin D supplementation on BP in hypertensive patients with vitamin D deficiency or insufficiency.
| Author (Ref) | Mean Age (Yrs) | % of HTN Subjects | Mean 25(OH)D (ng/ml) | Intervention | Findings (the changes in 25(OH)D and BP) | |
|---|---|---|---|---|---|---|
| 25(OH)D (ng/ml) | BP (mmHg) | |||||
| Krause et al (37) | 48 | 100 | 23 | Full body UVB (thrice-weekly, 6 wks, n=18) | 60 | ↓ 24-h SBP/DBP (-6/ -6) |
| Sudgen et al (67) | 64 | Not provided (82% taking anti-HTN drugs) | 15 | Vitamin D2 100,000IU once (8wks, n=34) | 21 | ↓ SBP (-14) |
| Witham et al (68) | 65 | 75 | 18 | Vitamin D2 1 or 200,000 IU once (8 wks, n=61) | 25 or 32 | ↓ SBP (- 8.2) or SBP(- 9.3) |
| Larsen et al (65) | 61 | 100 | 23 | Vitamin D3 3,000 IU daily (20 wks, n=112) | 44 | ↓ SBP (-6) and C-SBP(-7) 24-h SBP/DBP (-3/-1) In 92 vitamin D insufficient patients. ↓ 24-h SBP/DBP (-4/-3) |
| Chen et al (63) | 62 | 100 | 19 | Vitamin D3 2,000 IU daily (24 wks, n=126) | 34 | ↓24-h SBP/DBP (-6.2/-4.2) In 113 vitamin D insufficient patients ↓ 24-h SBP/DBP (-7.1/-5.7) |
| Mozaffari et al (66) | 43 | 100 | 18 | Vitamin D3 50,000 weekly (8 wks, n=42) | 52 | ↓ SBP/DBP (-6.4/-2.4) |
| Forman et al (64) | 51 | 50 | 16 | Vitamin D3 1,000, 2,000, 4,000 IU daily (12 wks, n=283) | 30,35 and 46 | SBP(-0.66, -3.4, -4.0) ↓ SBP(-1.4 per 1000 IU vitamin D3/d) |
| Arora et al (85) | 36 | 28 | 16 | Vitamin D3 4,000 IU daily (24 wks, n=383) | 33 | 24-h BP(-0.8/-1.2) |
| Scragg et al (91) | 48 | 15 | 29 | Vitamin D3 200,000 IU for 2 months, 100,100 IU/month for 16 months | 50 | SBP (- 0.6) |
↓
represents a significantly reduction of BP compared with placebo group.